CHEM GU4148

I learned more than organic chemistry and reactions for synthetic routes, I meet on of the best PI/Professors that I have ever meet, my opinion is not biased mainly because I was in her shoes a couple years before. And the way she managed the class and her openness is something that she should lose. I learned how to think retrosynthetically and how to tackle problems even when I did not how to start that skill in itself is super valuable.

I learnt myriads of reaction mechanisms, how to rationalize reaction mechanisms and predict reaction outcomes

I learned traditional synthetic problem solving skills. I also gained better insight on stereochemical models that can help me design new reaction motifs.

I learned more about the steric and electronic considerations in planning a specific reactions.

Through a careful examination of the reactions in the course, Prof. Makeda Tekle-Smith carefully and sophisticated highlighted how stereo-electronic effects can beautifully translate into diastereoselective and enatioselective transformations. I learnt how to view synthesis problems in an alternate light, learned how to spatially think about molecules and thus their reactivity, and gained a newfound appreciation for the vast array of transformations available in Organic Chemistry. I also learnt how with a few tools, you can analyse the stereoelectronic effects governing a reaction, regardless of whether or not you've seen them before.

Many new named reactions, transition state analysis/stereochemistry, retrosynthetic disconnections, research proposal writing

I would recommend this class to anyone who's interested in changed his/her/their perspective about organic chemistry, you'll learn a lot, but be mindful that you have to have relative strong organic chemistry toolkit in order to understand the nuances and other details of the class. Overall 9/10, specially with Makeda as professor.

If you are a student that wishes to expand upon what you learnt in sophomore organic chemistry, take this course. You will see things in a completely different light and you will hone your chemical intuition further. You'll also gain experience in preparing an original research proposal - an invaluable skill to build for anyone embarking on graduate studies.

This course is a great next step after introductory organic chemistry as sit goes into more depth on stereochemistry and introduces new reactions, but it is still challenging enough for students who have taken organic electives. 1 Columbia University: Arts & Sciences Fall 2022 Course: CHEMGU4148_001_2022_3-SYNTHETICMETHDS-ORGANCCHEM : CHEMGU4148_001_2022_3 - SYNTHETIC METHDS-ORGANC CHEM Instructor: Makeda Tekle Smith

Stereoelectronic effects; conformational analysis; olefin addition reactions; sigmatropic rearrangements; cycloadditions; stereoselective carbonyl addition, enolate reactions, and aldol reactions; olefin synthesis; oxidation/reduction; cross-coupling reactions, and radical chemistry. Think of this course like learning organic chemistry but from the perspective of geometrical logic.